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Figure 1 Figure 2 3 Mechanisms of action for GLP-1R agonists to control food intake GLP-1R agonists primarily act to reduce body weight by suppressing energy intake
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However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials
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