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One reason for the relationship between obesity and lower testosterone is that fat cells contain high levels of an enzyme that converts testosterone into oestradiol, the main female sex hormone

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The protocol was approved by the Ethics Committee for Animal Use (CEUA) of Universidade Federal do Rio Grande do Sul (UFRGS) (CEUA/UFRGS n 35823) and followed the guidelines of Conselho Nacional de Controle de Experimentao Animal (CONCEA) and experiments are reported in compliance with the ARRIVE guidelines 2.0 (du Sert et al., 2020)

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