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GLP-1 medications can reduce lean muscle mass along with fat

In separate Phase 2 and Phase 3 trials, retatrutide at 12mg produced greater total body weight reduction than semaglutide at 2.4mg across comparable timeframes, with the difference primarily attributable to retatrutides additional glucagon receptor activation

Though research is ongoing, this indicates potential for delaying the onset or progression of neurodegenerative diseases like Alzheimers

The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision