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It will require clinical trials by independent entities to delineate the true effectiveness and side effect profile of this and all new medications. Following the results of earlier trials, Novo Nordisk submitted a New Drug Application to the Food and Drug Administration (FDA) in December 2025 for the use of CagriSema to assist and maintain weight loss alongside diet and exercise adjustments

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showed that GPX4, ACSl4, iron and malondialdehyde (MDA) in myocardial ischemic tissue did not change significantly after 15, 30 or 60 min of coronary artery occlusion [88]

Los efectos adversos ms destacados han sido nuseas, vmitos y diarrea, pero no han hecho que los pacientes abandonaran el tratamiento