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Do not use Retatrutide as a substitute for approved care for obesity, diabetes, chronic weight management, or another health condition

These mediators include the inflammasome complex NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and tumor necrosis factor-alpha (TNF-), which in turn exacerbate the dendritic and synaptic impairments leading to neuronal death and promote AD progression [13,14,15]

Limited head-to-head trials exist