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Learning Objectives By the end of the self study you should be able to: Define the concepts of loading dose, bioavailability, volume of distribution (Vd), clearance & elimination half-life

As a research reagent it is used to probe type 1 IGF receptor activation, downstream PI3K and MAPK signalling, IGF binding protein biology, and the specific question of how much native IGF-I behaviour reflects IGFBP sequestration rather than receptor pharmacology

Ingesting too much of it can cause health complications

It involves removing small tissue pieces of the prostate from inside the gland using a scope through the urethra