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Specialist weight management services may consider medication changes if initial therapy proves ineffective or poorly tolerated, but this involves switching between agents rather than combining them

The first is that semaglutide is semaglutide the molecule that produced about 15% mean weight loss in STEP 1 (Wilding et al., 2021), that reduced food-cue reward signalling in van Bloemendaal's imaging (van Bloemendaal et al., 2014), that the broader incretin literature has characterised in detail (Drucker, 2018), does not become a different molecule because of where it was synthesised

They can also refer you to specialist services if needed, such as lipid clinics for complex dyslipidaemia or familial hypercholesterolaemia, or diabetes specialist teams for optimisation of diabetes management

doi:10.3390/nu15153483 4