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Benefits of GLP-1 Weight Loss Therapy Proven weight loss (average of 1520% body weight over 612 months) Decreased appetite and food cravings Improved blood sugar and insulin sensitivity Support for long-term behavior change Boosted confidence and mental well-being

The reasons for the lack of benefit of DPP-4 inhibitors on major cardiovascular outcomes could theoretically be related to the relatively short duration of follow-up in the landmark trials