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Weight regain after stopping GLP-1 drugs may plateau after time, researchers say Although people appear to regain weight rapidly after taking GLP-1 weight-loss drugs this may plateau after time, a new modelling study has reported

By contrast it calls mild nausea, constipation, and mild discomfort common during initiation and usually resolving within weeks

However, patients with multiple comorbidities or complex medication interactions may require more extensive evaluation before safe initiation

A systematic review and meta-analysis published in eClinicalMedicine reported pooled mean weight regain of 5.63 kg and 5.81 percent of body weight