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The images were acquired on a Tecnai 12 (Thermo Fisher Scientific) LaB 6 electron microscope operating at 120 kV using a Gatan Orius 1000 CCD camera or on a Tecnai F20 (Thermo Fisher Scientific) FEG electron microscope operating at 200 kV using a Ceta CMOS camera (Thermo Fisher Scientific)

Analysis of the crystal structures of EcGGT, HpGGT, BsGGT, and BlGGT in complex with glutamate demonstrated that the catalytic pocket is enclosed within the shallow groove at the interface of both large and small subunits (Okada et al., 2006

Trial discontinuation rates due to adverse events were modest (approximately 10-15% in higher dose groups)