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Description

Only about 1% of oral B12 is absorbed passively when intrinsic factor is absent or impaired

The coefficient of variation for plasma AUC (area under the curve) is 1218% for SubQ versus 2231% for IM across repeat dosing

In contrast, SAGE-DM is not a cluster-defined or statistically derived phenotype, but a mechanistically oriented framework emphasizing the role of aging biology rather than clinical clustering

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