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The higher GHK-Cu loading reflects its role as the matrix-remodeling and gene-expression workhorse of the formulation, while KPV has attracted growing research attention for its modulation of NF-B signaling and its emerging role in inflammatory bowel disease and skin inflammation models, complementing the systemic regenerative profile of the other three peptides

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Nanocarriers, including liposomes and polymeric nanoparticles, have the distinct advantage of encapsulating both hydrophilic and lipophilic components of a plant extract [347]