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FIGURE 9 FIGURE 10 FIGURE 11 FIGURE 12 FIGURE 13 In the aforementioned study by Hsieh and collaborators (Hsieh et al., 2017) that focused on the ischemic muscle model (achieved via removal of the femoral artery), the pro-angiogenic effects of BPC 157 are evident, given the increased expression, internalization of vascular endothelial growth factor receptor 2 (VEGFR2), and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017)
Patients at highest risk for deficiency and most likely to benefit from supplementation include those with limited sun exposure, dark skin pigmentation, malabsorption disorders, chronic kidney disease, and certain medications that interfere with vitamin D metabolism
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