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The results showed that GHK-Cu binds directly to SIRT1 and forms a protein complex, with the interacting amino acid residues GLU-230 and ASN-226 being identified (Li et al., 2025)

4.4 Therapeutic strategies targeting the ferroptosisbloodbrain barrier disruption axis in Alzheimers disease A growing body of evidence indicates a pathological interplay between ferroptosis and bloodbrain barrier (BBB) dysfunction in Alzheimers disease (AD)