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Precision diagnosis and future directions There are compelling reasons for seeking biologically meaningful classification systems based on diabetes heterogeneity across age groups, but greater evidence on the relative contribution of -cell dysfunction vs Direct evidence for insulin resistance in aging-associated diabetes is needed to further define SAGE-DM as an aging-related phenotype Future research priorities include: 1

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DREAMS-2: A Phase 3 clinical study comparing mazdutide versus dulaglutide in Chinese adults with type 2 diabetes who have poor glycemia control with oral medication