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393 Direct mitophagy enhancers include urolithin A, which induces mitophagy and improves mitochondrial function in AD and PD models, 394 and kinetin and its analog MTK458, which stabilize PINK1 and enhance Parkin-mediated mitophagy in PD models

Although the exact pathophysiology of NAION is unknown, it is understood to result from insufficient blood flow to the optic nerve head, the researchers wrote in their paper

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