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Below are the doses studied: Weekly injection: 1 mg 3 mg 6 mg 9 mg 6/9 mg (dose escalation) 3/6/9 mg (dose escalation) Some participants followed a step-up dosing schedule, meaning their dose was gradually increased over time

Our major insight from examining the vitamin B 12 GSH data in conjunction with the Reed-Nijhout model is that cysteine-block explains why GSH does not increase as a result of vitamin B 12 deficiency induced hyperhomocysteinemia

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Even partial denaturation that leaves the solution visually clear can compromise efficacy