At a psychological level, a lack of vitamin B12 can lead to listlessness, depressive mood, difficulty concentrating, nervousness, and sleep disorders
The standard research protocol is 300 mcg per day, subcutaneous, administered in a fasted state, typically in the morning before food or exercise
4 In asymptomatic patients with low-normal levels of vitamin B 12 (200 to 350 pg per mL [147.56 to 258.23 pmol per L]), elevated levels of the precursor compounds homocysteine and methylmalonic acid may prompt a decision to supplement patients with vitamin B 12
Concentration-dependent neurologic side effects: Cerebellar dysfunction: Nystagmus, ataxia, vertigo, dysarthria