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Our work on Mtb metabolism previously identified that enzymes of the anaplerotic (ANA) node of CCM have unique and essential roles in controlling the flux of carbon through Mtb (Basu et al, 2018

Coenzyme Q10 (CoQ10) has shown promising results in mitigating doxorubicin-induced cardiomyopathy

Key Terms Explained GHK Peptide (Glycyl-Histidyl-Lysine) A naturally occurring tripeptide that binds copper and stimulates tissue repair

GSH Quantification Glutathione and GSSG were measured in lysates from cells in 6-well plates as previously described ( ROS Quantification by Spin-Trapping and EPR Spectroscopy Cells (5 10 6 /0.1 ml) were stimulated for 2 h with LPS, then incubated with 50 mM 5-tert-butoxycarbonyl-5-methyl-1-pyrroline-N-oxide (BMPO), synthetized as described previously ( Cell Viability Assay Cells were seeded in 96-well plates at 25,000/well in complete medium