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This clearly shows that retatrutide, although it can increase cAMP in other cell types, does not increase as we hypothesized for the FOC in LA

These findings highlight that GLP-1-RA such as Ex-4 can promote hMSC proliferation, while native GLP-1 forms and Liraglutide predominantly exert inhibitory effects on proliferation and glucose uptake, with varying results under different conditions, highlighting their context-dependent role in hMSC behavior and metabolic regulation

For a deeper look at what GLP-1 medications can do to your digestion (and how to manage it), check out our guide on common side effects of Ozempic and Mounjaro

The manufacturers of these medications do not offer guidance in the prescribing information about tapering off the medication because they are intended to be chronic medications which means they can be taken safely forever, says Lofton