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Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)

Methods Ethics statement Data analysis utilizing the TriNetX platform received approval from the Institutional Review Board of Chi-Mei Hospital (No: 11202-002), as well as approval from the institutional review boards of all participating hospitals