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Dosing may differ slightly

If people stop medication, many are likely to need ongoing nutritional and behavioural support, and health services should anticipate that cardiometabolic benefits may lessen as weight is regained, Spreckley said, adding that this highlights the need for further research into effective, scalable strategies for long-term weight maintenance alongside pharmacotherapy. GLP-1 medications have become widely used in recent years, and more than 15 million Americans are now losing weight with the drugs

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Intranasal administration through the olfactory pathway could enable researchers to investigate retatrutide effects on brain GLP-1, GIP, and glucagon receptors without the confounding variable of high peripheral peptide levels