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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

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In a nutshell, the administration has signed agreements with pharmaceutical manufacturers Eli Lilly and Novo Nordisk that establish reduced pricing for a range of GLP-1 medications when purchased by Medicare and Medicaid and via TrumpRx, the Direct-To-Consumer prescription drug program set to go live early in 2026