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This maintenance or recovery of sphincter function by BPC 157 therapy might be contrary to different agents application, (i.e., absolute alcohol, NSAIDs and/or neuroleptics and/or NO-agents, and/or atropine (lower esophageal sphincter, pyloric sphincter, pupil) [107,108,109,110,111,112,113,114,115,117], cyclophosphamide (urinary sphincter) [91], and different (even opposite) dysfunctions, i.e., NOS-blockade, and NOS-over-activity [55,113])