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Diarrhoea (defined as three or more loose or watery stools per day) is an uncommon side effect of vitamin B12 supplementation , though it is listed as a rare or uncommon adverse reaction in the official product information for both oral cyanocobalamin and injectable hydroxocobalamin preparations

and (2) the 13-amino-acid leader sequence further reduces IGF-1R binding affinity approximately 3-fold compared to native IGF-1 while dramatically extending bioavailability by preventing IGFBP sequestration in biological matrices