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The elevated production of OPT is typically observed in APAP-overdosed mice [144], in patients with hepatic injury [142], and in fasted mice [145]

This naturally occurring tripeptide binds copper ions and is found in plasma, saliva, and urine

Neurosci Res 37:159, PMID: 10802340 Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats