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CONCLUSIN Los datos del estudio SOUL muestran una mejora de la salud cardiovascular en los pacientes con DM tipo 2 y enfermedad cardiovascular/renal establecida (aunque solo el 13% de los pacientes incluidos tena enfermedad renal crnica) a expensas principalmente de la reduccin de los infartos no fatales, sin efecto en la mortalidad cardiovascular ni eventos renales

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It is generally accepted that folate supplementation is safe, but higher doses, such as the 5 mg can potentially cause adverse gastrointestinal effects, such as abdominal cramps, nausea and diarrhea, sleep disorders, irritability, rash, and lower seizure thresholds in patient taking anticonvulsants

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