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Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: increased blood pressure / hypertension urinary tract infections nasopharyngitis constipation Pharmacokinetics: taken orally by tablet, 25 mg once daily metabolized via multiple pathways involving dealkylation, oxidation, glucuronidation, and hydrolysis 6-12% is eliminated unchanged by the kidney, involving glomerular filtration and active secretion that is dose-dependent Drug Interactions: mirabegron is a moderate inhibitor of CYP2D6 Notes: the estimated Walmart cost for Mybetriq oral 50mg tablets is ~$440 for a supply of 30 tablets (GoodRx.com

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Furthermore, the acetyl-CoA derived from carnitine has been also reported to regulate gene expression by influencing histone acetylation (Madiraju et al., 2009)

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