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One benefit of GLP-1 receptor agonists is that they do not cause hypoglycemia when combined with metformin or thiazolidinediones, but the dose of concomitant sulphonylurea or insulin may have to be decreased to reduce the risk of hypoglycemic episodes

Furthermore, CVOTs have documented the cardiovascular safety of the GLP-1 RA drug class in type 2 diabetes (Sattar et al., 2021)

During the 12-month time period, a lower incidence of acute pancreatitis was reported with olezarsen

The documented approach follows the same sequence used for any lyophilized GLP-1-class peptide: Let both components reach handling temperature and wipe the vial stopper and the bacteriostatic-water vial with fresh alcohol before every puncture