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USA 120 , e2213857120 (2023)
The method of embodiment 53, wherein the composition comprises between about 0.01% to about 20% by weight of the carbomer, about 0.01% to about 15% by weight of the carbomer, about 0.01% to about 10% by weight of the carbomer, about 0.01% to about 7% by weight of the carbomer, about 0.01% to about 5% by weight of the carbomer, about 0.01% to about 3% by weight of the carbomer, about 0.01% to about 2% by weight of the carbomer, or about 0.01% to about 1% by weight of the carbomer
MOF-mediated acetylation enhances NRF2 nuclear retention and downstream gene transcription, playing a critical role in antioxidant responses and drug resistance, and regulating tumor growth and resistance through an NRF2-dependent mechanism [58]
In the liver, they both have metabolic regulation actions, but IRS-2 has a more profound role in lipid metabolism [121]
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