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In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques Another study published in 2001 found the same thing, yet the results were very different for lean rats versus obese rats: Both hGH and AOD significantly reduced body weight gain in obese mice

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Traditionally, injection has been considered the most efficient route of administering peptide drugs

Eli Lilly has also raised concerns about the potential risks that compounded versions of its drugs pose to patients