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For example, over 72 weeks, people taking the highest maintenance dose of Mounjaro can lose up to 22.5% of their starting body weight, whereas people on the highest Wegovy maintenance dose can lose up to 21% of their body weight in 72 weeks

This strategy prevents competitive interference from endogenous ligands and antibodies by using the insulin receptor and integrin v as model targets, respectively, and can effectively overcome pseudotargets or target loss caused by shedding or mutating the extracellular domain of target receptors