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Combining complementary mechanisms theoretically offers additive metabolic benefits, but this remains largely evidence-based inference rather than proven clinical synergy in humans

Others develop asymmetric oligoarthritis, where one or two joints flare in an unpredictable pattern

doi: 10.3945/an.115.009639 38 VanekovZRollingerJM

6 Change from average baseline eGFR of 45 mL/min/1.73 m 2 : -0.35 mL/min/1.73 m 2 2 with Victoza 1.8 mg ( P =0.36) 2 +0.37 mL/min/1.73 m 2 2 with placebo 2 No dosage adjustment recommended for patients with renal impairment 1 There is limited experience with Victoza in patients with end-stage renal disease