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Tolerability was suggested to be more favorable in participants with obesity compared to those with overweight

In contrast, studies with semaglutide did not show a clinically relevant impact on the absorption of oral contraceptives, and thus its label does not carry this specific recommendation

For context, headache rates with tirzepatide and semaglutide are similar or slightly higher, suggesting this is more of a general weight-loss medication effect than something specific to cagrilintide pharmacology

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