Treatment of diet-induced obese mice with sitagliptin (4 g/kg), a DPP-4 inhibitor, significantly reduced the expression of inflammatory genes including monocyte chemotactic protein- (MCP-) 1, IL-6, IL-12(p40), IL-12(p35), and IFN- -induced protein 10 (IP-10) in pancreatic islets and improved glucose-stimulated insulin secretion in isolated islets [19]
When to Consult Your Healthcare Provider About GLP-1 Side Effects While constipation from GLP-1 medications is common, certain symptoms warrant medical attention: Severe abdominal pain Blood in stool Unexplained weight loss, hard to tell when youre on GLP-1s though Constipation that alternates with diarrhea Symptoms that persist despite lifestyle changes and over-the-counter remedies Constipation that begins suddenly and represents a significant change Your healthcare provider might: Adjust your GLP-1 medication dosage Recommend prescription medications for constipation Evaluate for other potential causes of constipation Consider temporarily pausing treatment if symptoms are severe Balancing Benefits and Side Effects of GLP-1 Weight Loss Drugs For many patients, the benefits of GLP-1 medications for weight loss or diabetes management outweigh the inconvenience of constipation
Like tendons, fistulas are notoriously difficult to treat
The trial enrolled 76 adults with type 2 diabetes and randomized them to placebo, a three-strain formula or the five-strain formula now sold as Glucose Control After 12 weeks, the group taking the five-strain probiotic saw a statistically significant improvement in post-meal blood sugar spikes and total glucose response after a test meal compared with the placebo group
