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We note that because of the low amount of DNA that was obtained for the germline LAG-1 ChIP-seq experiments, it is possible that we missed some weak ChIP-seq peaks

With extensive Phase 3 data across diabetes (SUSTAIN trials) and obesity (STEP trials), Semaglutide serves as a benchmark comparator for researchers studying newer metabolic peptides including Tirzepatide and Retatrutide

Rotarod Motor coordination and balance were assessed using an accelerating rotarod (Panlab, Harvard apparatus, Cambridge, UK)

Additionally, there was no systematic measurement or control for tobacco use, despite evidence indicating that nicotine exerts an effect on GLP-1, which may contribute to reduced feelings of hunger [49]