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[1] [3] A version of semaglutide to treat diabetes that can be taken orally (Rybelsus) was approved for medical use in the US in September 2019, [86] [87] and in the European Union in April 2020

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We believe that the receptor uses the ER as a bridge to access other cellular organelles, opening exciting possibilities to find new ways to improve diabetes therapies." Professor Alejandra Tomas Catala Department of Metabolism, Digestion and Reproduction The paper, published in Nature Communications, uncovers how the GLP-1 receptor (GLP-1R) forms a specialised signalling hub inside pancreatic -cells that supports healthy mitochondria and boosts insulin secretion