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[] PCa, in its early stages, may present symptoms such as excessive urination, frequent nighttime urination (nocturia), difficulty in initiating and maintaining regular urination, blood in the urine (hematuria), and painful urination (dysuria)

IGF-1 is best thought of as a maturation hormone because it not only promotes cell proliferation, but differentiation as well

Materials and methods Establishment of PCOS mouse model Four-week-old female C57BL/6 mice (Guangdong Medical Laboratory Animal Center) were housed at 22 2C with a 12-h light/dark cycle and given standard feed and water ad libitum