At supplemental doses of 3 to 5 grams per day, which is the range studied for sleep and metabolic benefits, glycine is generally recognized as safe
Highlights: GLP-1 synthesis, metabolism, and the expression of the receptor show diversity across tissues
This work was supported by the JSPS KAKENHI (JP17H03674, JP21H05047, JP20KK0341, JP20H03252, JP24H01286, and JP24K02024) (S.S.), JST CREST (JPMJCR1863 and JPMJCR24B3) (S.S.), JST CREST (JPMJCR24B3) (T.I.), JST CREST (JPMJCR24B3) (K.G.N.S.), Uehara Memorial Foundation (S.S.), Takeda Science Foundation (S.S.), the National Institute of Health (R35GM149329) (T.I.), the National Science Foundation (000819255) (T.I.), JST FOREST Program (JPMJFR2413) (T.N.), JSPS KAKENHI (JP17K07427, JP20K06625 and JP23H02476) (T.N.), and 2021 NAIST University Fellowships for the Creation of Innovation in Science and Technology (T.F.)
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