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One major mediator of this event is transforming growth factor-beta (TGF-), which is secreted by the tumor stroma and participates in a paracrine signaling loop with tumor cells [19]

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NO and polyamine synthesis compete for often-limiting L-arginine and L-ornithine synthetic substrates (Figure 1), with important implications for key receptors of nitrergic neurotransmission

Over the past few years, we have seen the vital roles the metal nanomedicines play in the GSH-responsive and -exhausting strategies, and inorganic nanomaterials, MOFs, and platinum-based nanomaterials-mediated GSH depletion is expected to realize more powerful synergistic therapy based on rational design