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Detection methods are then developed for both parent compounds and key metabolites

As demonstrated in Figure 3, PCPA significantly decreased plasma 5-HT levels in wild type mice, which was accompanied by elevations in AST, ALT levels and liver necrosis and the reduction of 5-day's survival

Kira J, Tobimatsu S, Goto I

Incremental areas under plasma glucose and insulin curves (AUC) were calculated using a computer-generated program (CAREA) using the trapezoidal rule [34] with baseline subtraction where appropriate