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Firstly, the extent to which GLP-1R signaling regulates immune cell biology: are these signaling pathways primary mediators or co-participants in the immune response

Recent studies demonstrated that individuals with glutathione transferase omega polymorphisms, genotype variants GSTO1*AA (rs4925) and GSTO2*GG (rs156697), showed significant propensity towards development of clinical manifestations in COVID-19 supporting the significance of these enzymes in the regulation of redox homeostasis and immune response, especially NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation (Zhao and Zhao, 2020

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ACE2: the major cell entry receptor for SARS-CoV-2