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Considering the putative role of oxidative stress as a pathogenetic factor for the development of colitis and because the reductive metabolism of TNBS has been shown to generate ROS, this model of colitis was chosen to evalute the temporal relationship between the levels of GSH in mucosa and the appearance and extent of injury in vivo during the acute phase of colitis in TNBS+ethanol-treated rats and to determine the effect of NAC administration on mucosal GSH levels and extent of injury

Messlinger K

However, the broad spectrum of symptoms belonging to either musculoskeletal or cardiorespiratory symptom clusters was similar in both wild-type and VOC infections, though more studies with higher number of observations/patients are needed to confirm the effects (183)

For instance, nanocarriers co-delivering PTT agents and chemotherapy drugs can enhance synergistic effects, improving treatment outcomes