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Table 4 shows a comprehensive summary of treatment strategies, categorized by the level of supporting evidence to enhance clinical applicability and translational relevance

Oral doses of 0.55mg are most common in published research, but 4060% first-pass metabolism means actual CNS exposure is significantly lower than nominal dose

Vitamin E [5] Vitamin B2 [6] Glutathione level is significantly related to Vitamin E level, and supplementation with Vitamin E (100 IU/day) significantly increases Glutathione and lowers lipid per-oxidation and HbA1c concentrations in the erythrocytes of type 1 diabetic patients

Peter : The 2/4 is about the same as the 3/3