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For drugs that are highly extracted by the liver, bypassing hepatic sites of elimination (eg, in hepatic cirrhosis with portosystemic shunting) will result in substantial increases in drug availability, whereas for drugs that are poorly extracted by the liver (for which the difference between entering and exiting drug concentration is small), shunting of blood past the liver will cause little change in availability

Telehealth is popular in Omaha precisely because the metro is spread out and winter driving on I-80 is no fun

The first MASH drug therapy on the horizon: current perspectives of resmetirom

Then, in March 2026, Novos semaglutide patent expired in India, triggering expectations of a major generic wave