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doi: 10.3390/nu8110745
Indeed, thyroid dysfunction is the most frequent endocrine irAE and may affect up to 40% of patients receiving ICIs (Baraka et al
Fibroblast Growth Factor (FGF21) Fibroblast growth factor (FGF) 21, expressed primarily in the liver, but also found in adipose tissue, skeletal muscle, and pancreas, is a member of the FGF family and acts as a metabolic regulator of body weight, glucose metabolism, and lipid metabolism (237)
proBDNF plays a contrasting role by inducing negative neuroplasticity mechanisms (e.g., long-term depression, pruning, and neural apoptosis) through its specific molecular pathways [30]
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