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For fatigue If fatigue is your primary issue, consider these adjustments: Reduce dose by 25-50% until adaptation occurs Increase carbohydrate intake to support energy needs Ensure adequate sleep, ideally 7-9 hours nightly Time doses to morning rather than evening Add a rest week every 3-4 weeks of use Consider supporting mitochondrial function with CoQ10 or NAD+ precursors Fatigue typically resolves within 2-3 weeks if your protocol is otherwise appropriate

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Withhold dapagliflozin and metformin hydrochloride extended-release tablets for at least 3 days, if possible, prior to surgery or procedures associated with prolonged fasting