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This indicates that overdosing with APAP triggers mitochondrial dysfunction as a consequence of NAPQI binding to mitochondrial proteins, which is also associated with ROS generation and inhibition of mitochondrial respiration (4951), and a decrease in ATP levels (52

Am J Psychiatry (2015) 172(6):5708

Clinicians monitor patient progress carefully during the first month to ensure treatment remains safe and well tolerated

Giving blood can help manage side effects like: Sleep apnea from thickened blood Strain on the heart from high hematocrit levels Increased clotting risk if blood gets too viscous Your doctor can evaluate if the advantages of donation fit your specific treatment plan