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Ochronosis was most often reported in middle-aged women (53.2%), of African descent (45.2%), Black races (55.5%), and Fitzpatrick skin types V-VI (52.4%)

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SDF-1 is thus discussed in the literature as important mediator of cardioprotective effects addressed to the use of DPP4 inhibitors (further discussed in DPP4 Substrates: SDF-1- and BNP-Dependent Effects of DPP4 Inhibitors)

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