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The mechanism is specific and brutal: hypothalamic damage reduces production of alpha-melanocyte-stimulating hormone (-MSH), a neuropeptide that under normal conditions activates the melanocortin-4 receptor (MC4R)

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However, to date, there isapart from a letter to the editor by Goncalves and Bell [12]no data for efficacy and safety when patients are treated with any type of GLP-1 agonist whether a switch to semaglutide is effective